X-ray, NMR, and cryo-EM methods revolutionized our understanding of protein structures. Yet, our knowledge about the dynamics of proteins and even more so, of cells, is lagging far behind. Living systems are four-dimensional objects. Proteins sample a multitude of structures at timescales from nanoseconds to hours. Genes are expressed in bursts, i.e., stochastically in time, thus causing tremendous variability in cell populations. Our research bridges this gap between the structure-driven research in classical Structural Biology and the model-based approach in Chemical Physics and Systems Biology.